Cocaine addiction as a homeostatic reinforcement learning disorder.

An integrated homeostatic reinforcement learning theory of motivation explains the transition to cocaine addiction

Cocaine addiction as a neurological disorder: implications for treatment.

Clinical and preclinical studies provide convincing evidence for persistent neurological/psychiatric impairments and possible neuronal degeneration associated with chronic cocaine/stimulant abuse. These impairments include multifocal and global cerebral ischemia, cerebral hemorrhages, infarctions, optic neuropathy, cerebral atrophy, cognitive impairments, and mood and movement disorders. These ...

A Reinforcement Learning Theory for Homeostatic Regulation

Reinforcement learning models address animal’s behavioral adaptation to its changing “external” environment, and are based on the assumption that Pavlovian, habitual and goal-directed responses seek to maximize reward acquisition. Negative-feedback models of homeostatic regulation, on the other hand, are concerned with behavioral adaptation in response to the “internal” state of the animal, and...

Curiosity-driven reinforcement learning with homeostatic regulation

We propose a curiosity reward based on information theory principles and consistent with the animal instinct to maintain certain critical parameters within a bounded range. Our experimental validation shows the added value of the additional homeostatic drive to enhance the overall information gain of a reinforcement learning agent interacting with a complex environment using continuous actions....

Collecting reward to defend homeostasis: A homeostatic reinforcement learning theory

Efficient regulation of internal homeostasis and defending it against perturbations requires complex behavioral strategies. However, the computational principles mediating brain’s homeostatic regulation of reward and associative learning remain undefined. Here we use a definition of primary rewards, as outcomes fulfilling physiological needs, to build a normative theory showing how learning mot...